5/29/2023 0 Comments Atropine antidoteSince physostigmine is rapidly destroyed, the patient may again lapse into coma after one to two hours, and repeated doses may be required.Īrtificial respiration with oxygen may be necessary. Physostigmine, given as an atropine antidote by slow intravenous injection of 1 to 4 mg (0.5 to 1 mg in pediatric populations), rapidly abolishes delirium and coma caused by large doses of atropine. Large doses for sedation should be avoided because central depressant action may coincide with the depression occurring late in atropine poisoning. In the event of toxic overdosage, a short acting barbiturate or diazepam may be given as needed to control marked excitement and convulsions. In pediatric populations, 10 mg or less may be fatal. The fatal adult dose of atropine is not known. In such cases, blood pressure declines and death due to respiratory failure may ensue following paralysis and coma. Depression and circulatory collapse occur only with severe intoxication. ![]() ![]() Toxic doses lead to restlessness and excitement, hallucinations, delirium and coma. ![]() Excessive dosing may cause palpitation, dilated pupils, difficulty in swallowing, hot dry skin, thirst, dizziness, restlessness, tremor, fatigue and ataxia.
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